Polytechnic Institute
of Bragança



CIMO - Mountain Research Center. See video HERE


Rui Miguel Vaz de Abreu

Auxiliary Professor
Group: Sustainable Processes and Products
Phone: 273303244
ORCID: 0000-0002-7745-8015
Scopus Author ID: 7003290613


  • Since 2011: Auxiliary Professor, Instituto Politécnico de Bragança, Bragança, Portugal
  • 1998 - 2011: Assistant Professor, Instituto Politécnico de Bragança, Bragança, Portugal


  • 2011 - in Comparative and Molecular Genetics, Universidade de Trás-os-Montes e Alto Douro, Portugal
  • 2001 - in Molecular and Celular Biology, Universidade de Coimbra, Portugal
  • 1997 - in Biochemistry, Universidade de Coimbra, Portugal


  • Antitumour and anti-angiogenic activity of synthesized compounds: cell lines culture and enzymatic assays.
  • Application and software development of pharmacoinformatics in silico techniques including: molecular docking, MD simulations and QSAR analysis.


BEONNAT - Innovative value chains from tree & shrub species grown in marginal lands as a source of biomass for bio-based industries
Funding body: Horizon 2020
Reference: BBI-2019-SO1-R1 - 887917 – BEONNAT
Principal Investigator:Lillian Bouçada de Barros
Start: 2020-07-01
End: 2025-06-30
Aquavitae - Thermal water as a source of life and health
Funding body: PROMOVE 2020
Reference: PD20-00003
Principal Investigator:Lillian Bouçada de Barros
Start: 2021-09-01
End: 2024-05-31
WASTESILK - Silk Sericin as an industrial wastewater with valuable biomedical potential
Funding body: FCT
Principal Investigator:Lillian Bouçada de Barros
Start: 2021-01-01
End: 2024-01-01
LOCALNUTLEG - Developing of innovative plant- based added-value food products through the promotion of LOCAL Mediterranean NUT and LEGume crops
Funding body: PRIMA - TOPIC: 1.3.1-2020 (IA) Valorising the health benefits of the Traditional Mediterranean food products
Principal Investigator:Lillian Bouçada de Barros
Start: 2021-01-01
End: 2024-01-01
PulpIng - Development of Pumpking Pulp Formulations using a Sustainable Integrated Strategy Participant No PI name Organisation
Funding body: FCT/PRIMA
Reference: PRIMA/0007/2019
Principal Investigator:Lillian Bouçada de Barros
Start: 2020-09-01
End: 2023-08-31
HealthyPETFOOD - Formulações PetFood para promoção da saúde e qualidade de vida
Funding body: POCI-FEDER
Principal Investigator:Lillian Bouçada de Barros
Start: 2020-01-10
End: 2023-06-30
VALORNATURAL - Valorização de Recursos Naturais através da Extração de Ingredientes de Elevado Valor Acrescentado para Aplicações na Indústria Alimentar
Funding body: PORTUGAL 2020- SI-IDT - Programas mobilizadores
Principal Investigator:Lillian Bouçada de Barros
Start: 2018-09-01
End: 2022-02-28
MAGLIDUO - MAGnetoLIposomes for DUal cancer therapy
Funding body: FCT-SAICT
Reference: POCI-01-0145-FEDER-028020
Principal Investigator:Lillian Bouçada de Barros
Start: 2018-07-01
End: 2021-12-31
PlantCovid - Aplicações de extratos de plantas com ação dirigida ao SARS-CoV-2
Funding body: I&D Empresas - COVID19
Reference: NORTE-01-02B/-FEDER-054870
Principal Investigator:Lillian Bouçada de Barros
Start: 2020-07-14
End: 2021-07-13
DeCodE - Bring natural colorants and preservers into a real alternative to artificial additives through a strategy of open data and experience based research
Funding body: FCT-SAICT
Principal Investigator:Isabel Cristina Fernandes Rodrigues Ferreira
Start: 2017-04-01
End: 2019-10-01
AROMAP - Preservation of aromatic condiment plants
Funding body: PRODER - Medida 4.1
Principal Investigator:Isabel Cristina Fernandes Rodrigues Ferreira
Start: 2014-05-01
End: 2016-10-31
PlantLact - New functional dairy products without synthetic preservatives
Funding body: PRODER - Medida 4.1
Principal Investigator:Isabel Cristina Fernandes Rodrigues Ferreira
Start: 2014-01-01
End: 2015-12-31
- New antitumor and antiangiogenic heterocyclic compounds: synthesis, molecular modeling, screening of enzymatic inhibition and studies in tumor and endothelial cell lines with tyrosine kinase membrane receptors as targets
Funding body: PTDC - Projectos em todos os domínios científicos
Reference: PTDC/QUI-QUI/111060/2009
Principal Investigator:Isabel Cristina Fernandes Rodrigues Ferreira
Start: 2010-10-01
End: 2014-06-23
- Portuguese wild mushrooms: chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
Funding body: PTDC - Projectos em todos os domínios científicos
Reference: PTDC/AGR-ALI/110062/2009
Principal Investigator:Isabel Cristina Fernandes Rodrigues Ferreira
Start: 2010-12-24
End: 2013-12-24
- Bioactive properties of wild edible mushroomes
Funding body: Programa POCI 2010 – Medida V. 4 – Acção V.4.1
Reference: POCI/AGR/56661/2004 and PPCDT/AGR/56661/2004
Principal Investigator:Isabel Cristina Fernandes Rodrigues Ferreira
Start: 2005-10-01
End: 2008-09-30
- Estratégias para a minimização da Safra e contra safra do olival
Funding body: Programa AGRO, Medida 8, Acção 8.1
Principal Investigator:Manuel Ângelo Rosa Rodrigues
Start: 2003-01-01
End: 2007-01-01

Total results: 45
Serrano C.,Sapata M.,Oliveira M.C.,Soares A.,Pereira C.,Abreu R.M.V.,Barros L.
Encapsulation of Sorghum Leaf Red Dye: Biological and Physicochemical Properties and Effect on Stability
Foods, 12, , 2023

Shiraishi C.S.H.,Zbiss Y.,Roriz C.L.,Dias M.I.,Prieto M.A.,Calhelha R.C.,Alves M.J.,Heleno S.A.,da Cunha Mendes V.,Carocho M.,Abreu R.M.V.,Barros L.
Fig Leaves (Ficus carica L.): Source of Bioactive Ingredients for Industrial Valorization
Processes, 11, , 2023

Calhelha R.C.,Shiraishi C.S.H.,Ribeiro L.,Carocho M.,Abreu R.,Coutinho P.,Barros L.,Vaz J.,Ferreira I.C.F.R.
New trends from fungi secondary metabolism in the pharmaceutical industry
Natural Secondary Metabolites: From Nature, Through Science, to Industry, 823-850, 2023

Novais C.,Molina A.K.,Abreu R.M.V.,Santo-Buelga C.,Ferreira I.C.F.R.,Pereira C.,Barros L.
Natural Food Colorants and Preservatives: A Review, a Demand, and a Challenge
Journal of Agricultural and Food Chemistry, 70, 2789-2805, 2022

Rodrigues M.J.,Castañeda-Loaiza V.,Monteiro I.,Pinela J.,Barros L.,Abreu R.M.V.,Oliveira M.C.,Reis C.,Soares F.,Pousão-Ferreira P.,Pereira C.G.,Custódio L.
Metabolomic profile and biological properties of sea lavender (Limonium algarvense erben) plants cultivated with aquaculture wastewaters: Implications for its use in herbal formulations and food additives
Foods, 10, , 2021

De Oliveira A.,Moreira T.F.M.,Pepinelli A.L.S.,Costa L.G.M.A.,Leal L.E.,Da Silva T.B.V.,Gonçalves O.H.,Porto Ineu R.,Dias M.I.,Barros L.,Abreu R.M.V.,Ferreira I.C.F.R.,Bracht L.,Leimann F.V.
Bioactivity screening of pinhão (: Araucaria Angustifolia (Bertol.) Kuntze) seed extracts: The inhibition of cholinesterases and α-amylases, and cytotoxic and anti-inflammatory activities
Food and Function, 12, 9820-9828, 2021

Cardoso R.V.C.,Fernandes Â.,Barreira J.C.M.,Abreu R.M.V.,Mandim F.,Gonzaléz-Paramás A.M.,Ferreira I.C.F.R.,Barros L.
A case study on surplus mushrooms production: Extraction and recovery of vitamin d2
Agriculture (Switzerland), 11, , 2021

Pantuzza Silva G.F.,Pereira E.,Melgar B.,Stojković D.,Sokovic M.,Calhelha R.C.,Pereira C.,Abreu R.M.V.,Ferreira I.C.F.R.,Barros L.
Eggplant fruit (Solanum melongena l.) and bio‐residues as a source of nutrients, bioactive compounds, and food colorants, using innovative food technologies
Applied Sciences (Switzerland), 11, 1-24, 2021

Rocha R.,Pinela J.,Abreu R.M.V.,Añibarro-Ortega M.,Pires T.C.S.P.,Saldanha A.L.,Alves M.J.,Nogueira A.,Ferreira I.C.F.R.,Barros L.
Extraction of anthocyanins from red raspberry for natural food colorants development: Processes optimization and in vitro bioactivity
Processes, 8, 1-19, 2020

Ziani B.E.C.,Carocho M.,Abreu R.M.V.,Bachari K.,Alves M.J.,Calhelha R.C.,Talhi O.,Barros L.,Ferreira I.C.F.R.
Phenolic profiling, biological activities and in silico studies of Acacia tortilis (Forssk.) Hayne ssp. raddiana extracts
Food Bioscience, 36, , 2020

Albuquerque B.R.,Pereira C.,Calhelha R.C.,José Alves M.,Abreu R.M.V.,Barros L.,Oliveira M.B.P.P.,Ferreira I.C.F.R.
Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with bioactive properties
Food Chemistry, 309, , 2020

Vieira V.,Pereira C.,Abreu R.M.V.,Calhelha R.C.,Alves M.J.,Coutinho J.A.P.,Ferreira O.,Barros L.,Ferreira I.C.F.R.
Hydroethanolic extract of Juglans regia L. green husks: A source of bioactive phytochemicals
Food and Chemical Toxicology, 137, , 2020

Palmeira L.,Pereira C.,Dias M.I.,Abreu R.M.V.,Corrêa R.C.G.,Pires T.C.S.P.,Alves M.J.,Barros L.,Ferreira I.C.F.R.
Nutritional, chemical and bioactive profiles of different parts of a Portuguese common fig (Ficus carica L.) variety
Food Research International, 126, , 2019

Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Phytochemical profile and biological activities of 'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest
Food Chemistry, 294, 302-308, 2019

Garcia J.A.A.,Corrêa R.C.G.,Barros L.,Pereira C.,Abreu R.M.V.,Alves M.J.,Calhelha R.C.,Bracht A.,Peralta R.M.,Ferreira I.C.F.R.
Chemical composition and biological activities of Juçara (Euterpe edulis Martius) fruit by-products, a promising underexploited source of high-added value compounds
Journal of Functional Foods, 55, 325-332, 2019

Mosbah H.,Chahdoura H.,Mannai A.,Snoussi M.,Aouadi K.,Abreu R.M.V.,Bouslama A.,Achour L.,Selmi B.
Biological Activities Evaluation of Enantiopure Isoxazolidine Derivatives: In Vitro, In Vivo and In Silico Studies
Applied Biochemistry and Biotechnology, 187, 1113-1130, 2019

Lockowandt L.,Pinela J.,Roriz C.,Pereira C.,Abreu R.,Calhelha R.,Alves M.,Barros L.,Bredol M.,Ferreira I.
Chemical features and bioactivities of cornflower (Centaurea cyanus L.) capitula: The blue flowers and the unexplored non-edible part
Industrial Crops and Products, 128, 496-503, 2019

Mandim F.,Barros L.,Calhelha R.,Abreu R.,Pinela J.,Alves M.,Heleno S.,Santos P.,Ferreira I.
Calluna vulgaris (L.) Hull: Chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
Food and Function, 10, 78-89, 2019

Finimundy T.C.,Barros L.,Calhelha R.C.,Alves M.J.,Prieto M.A.,Abreu R.M.V.,Dillon A.J.P.,Henriques J.A.P.,Roesch-Ely M.,Ferreira I.C.F.R.
Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds
Food Chemistry, 245, 150-158, 2018

Ribeiro A.,Abreu R.M.V.,Dias M.M.,Barreiro M.F.,Ferreira I.C.F.R.
Antiangiogenic compounds: well-established drugs versus emerging natural molecules
Cancer Letters, 415, 86-105, 2018

Finimundy T.,Abreu R.,Bonetto N.,Scariot F.,Dillon A.,Echeverrigaray S.,Barros L.,Ferreira I.,Henriques J.,Roesch-Ely M.
Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines
Food and Chemical Toxicology, 112, 383-392, 2018

Oliveira F.S.,Ribeiro A.,Barros L.,Calhelha R.C.,Barreira J.C.M.,Junior B.D.,Abreu R.M.V.,Barreiro M.F.,Ferreira I.C.F.R.
Evaluation of Arenaria montana L. hydroethanolic extract as a chemopreventive food ingredient: A case study focusing a dairy product (yogurt)
Journal of Functional Foods, 38, 214-220, 2017

Merski M.,Moreira C.,Abreu R.M.V.,Ramos M.J.,Fernandes P.A.,Martins L.M.,Pereira P.J.B.,Macedo-Ribeiro S.
Molecular motion regulates the activity of the mitochondrial serine protease HtrA2
Cell Death and Disease, 8, , 2017

Liberal Â.,Calhelha R.C.,Pereira C.,Adega F.,Barros L.,Dueñas M.,Santos-Buelga C.,Abreu R.M.V.,Ferreira I.C.F.R.
A comparison of the bioactivity and phytochemical profile of three different cultivars of globe amaranth: Red, white, and pink
Food and Function, 7, 679-688, 2016

Guimarães R.,Calhelha R.,Froufe H.,Abreu R.,Carvalho A.,Queiroz M.,Ferreira I.
Wild Roman chamomile extracts and phenolic compounds: Enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase
Food and Function, 7, 79-83, 2016

Machado V.A.,Peixoto D.,Costa R.,Froufe H.J.C.,Calhelha R.C.,Abreu R.M.V.,Ferreira I.C.F.R.,Soares R.,Queiroz M.J.R.P.
Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors
Bioorganic and Medicinal Chemistry, 23, 6497-6509, 2015

Alves M.J.,Froufe H.J.C.,Costa A.F.T.,Santos A.F.,Oliveira L.G.,Osório S.R.M.,Abreu R.M.V.,Pintado M.,Ferreira I.C.F.R.
Docking studies in target proteins involved in antibacterial action mechanisms: Extending the knowledge on standard antibiotics to antimicrobial mushroom compounds
Molecules, 19, 1672-1684, 2014

Santos S.,Baptista C.S.,Abreu R.M.V.,Bastos E.,Amorim I.,Gut I.G.,Gärtner F.,Chaves R.
ERBB2 in cat mammary neoplasias disclosed a positive correlation between RNA and protein low expression levels: A model for erbB-2 negative human breast cancer
PLoS ONE, 8, , 2013

Queiroz M.,Peixoto D.,Calhelha R.,Soares P.,Dos Santos T.,Lima R.,Campos J.,Abreu R.,Ferreira I.,Vasconcelos M.
New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death
European Journal of Medicinal Chemistry, 69, 855-862, 2013

Soares P.,Costa R.,Froufe H.J.C.,Calhelha R.C.,Peixoto D.,Ferreira I.C.F.R.,Abreu R.M.V.,Soares R.,Queiroz M.J.R.P.
1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies
BioMed Research International, 2013, , 2013

Froufe H.,Abreu R.,Ferreira I.
Virtual screening of low molecular weight mushrooms compounds as potential Mdm2 inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 28, 569-575, 2013

Alves M.J.,Ferreira I.C.F.R.,Froufe H.J.C.,Abreu R.M.V.,Martins A.,Pintado M.
Antimicrobial activity of phenolic compounds identified in wild mushrooms, SAR analysis and docking studies
Journal of Applied Microbiology, 115, 346-357, 2013

Rodrigues S.,Calhelha R.C.,Barreira J.C.M.,Dueñas M.,Carvalho A.M.,Abreu R.M.V.,Santos-Buelga C.,Ferreira I.C.F.R.
Crataegus monogyna buds and fruits phenolic extracts: Growth inhibitory activity on human tumor cell lines and chemical characterization by HPLC-DAD-ESI/MS
Food Research International, 49, 516-523, 2012

Calhelha R.,Ferreira I.,Peixoto D.,Abreu R.,Vale-Silva L.,Pinto E.,Lima R.,Alvelos M.,Vasconcelos M.,Queiroz M.
Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells
Molecules, 17, 3834-3843, 2012

Abreu R.M.V.,Froufe H.J.C.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
Selective Flexibility of Side-Chain Residues Improves VEGFR-2 Docking Score using AutoDock Vina
Chemical Biology and Drug Design, 79, 530-534, 2012

Froufe H.,Abreu R.,Ferreira I.
QCAR models to predict wild mushrooms radical scavenging activity, reducing power and lipid peroxidation inhibition
Chemometrics and Intelligent Laboratory Systems, 109, 192-196, 2011

Abreu R.M.V.,Ferreira I.C.F.R.,Calhelha R.C.,Lima R.T.,Vasconcelos M.H.,Adega F.,Chaves R.,Queiroz M.J.R.P.
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2- carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies
European Journal of Medicinal Chemistry, 46, 5800-5806, 2011

Abreu R.M.V.,Froufe H.J.C.,Daniel P.O.M.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
Chemt, an open-source software for building template-based chemical libraries
SAR and QSAR in Environmental Research, 22, 603-610, 2011

Froufe H.,Abreu R.,Ferreira I.
Using molecular docking to investigate the anti-breast cancer activity of low molecular weight compounds present on wild mushrooms
SAR and QSAR in Environmental Research, 22, 315-328, 2011

Abreu R.M.V.,Froufe H.J.C.,Queiroz M.J.R.P.,Ferreira I.C.F.R.
MOLA: A bootable, self-configuring system for virtual screening using AutoDock4/Vina on computer clusters
Journal of Cheminformatics, 2, , 2010

Froufe H.J.C.,Abreu R.M.V.,Ferreira I.C.F.R.
A QCAR model for predicting antioxidant activity of wild mushrooms
SAR and QSAR in Environmental Research, 20, 579-590, 2009

Ferreira I.C.F.R.,Barros L.,Abreu R.M.V.
Antioxidants in wild mushrooms
Current Medicinal Chemistry, 16, 1543-1560, 2009

Abreu R.M.V.,Ferreira I.C.F.R.,Queiroz M.J.R.P.
QSAR model for predicting radical scavenging activity of di(hetero)arylamines derivatives of benzo[b]thiophenes
European Journal of Medicinal Chemistry, 44, 1952-1958, 2009

Abreu R.,Falcão S.,Calhelha R.C.,Ferreira I.C.F.R.,Queiroz M.J.R.P.,Vilas-Boas M.
Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene through the redox profile
Journal of Electroanalytical Chemistry, 628, 43-47, 2009

Abreu R.M.V.,Santos D.J.S.L.,Moreno A.J.M.
Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress
Journal of Pharmacology and Experimental Therapeutics, 295, 1022-1030, 2000